H Bobby Gaspar Selected Research

Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)

1/2022	Long-Term Immune Recovery After Hematopoietic Stem Cell Transplantation for ADA Deficiency: a Single-Center Experience.
12/2021	Metabolite and thymocyte development defects in ADA-SCID mice receiving enzyme replacement therapy.
1/2021	Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency.
6/2020	Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID.
1/2019	Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency.
5/2017	How We Manage Adenosine Deaminase-Deficient Severe Combined Immune Deficiency (ADA SCID).
9/2015	Chronic Infection with Rotavirus Vaccine Strains in UK Children with Severe Combined Immunodeficiency.
3/2014	Preclinical demonstration of lentiviral vector-mediated correction of immunological and metabolic abnormalities in models of adenosine deaminase deficiency.
1/2014	Tearing RAGs apart.
3/2012	Transplantation in patients with SCID: mismatched related stem cells or unrelated cord blood?

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H Bobby Gaspar Research Topics

Disease

25	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2022 - 10/2004
19	Severe combined immunodeficiency due to adenosine deaminase deficiency 01/2022 - 09/2005
10	Infections 01/2020 - 01/2007
6	X-Linked Combined Immunodeficiency Diseases (X Linked Severe Combined Immunodeficiency) 06/2018 - 12/2004
4	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 01/2018 - 08/2005
4	Graft vs Host Disease (Graft-Versus-Host Disease) 02/2014 - 09/2006
3	Neoplasms (Cancer) 12/2021 - 01/2018
3	Virus Diseases (Viral Diseases) 04/2015 - 09/2006
2	Lymphopenia (Lymphocytopenia) 01/2019 - 01/2016
2	Leukemia 06/2018 - 10/2014
2	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 01/2018 - 04/2015
2	Bone Marrow Failure Disorders 01/2018 - 01/2017
2	Wiskott-Aldrich Syndrome 01/2017 - 04/2015
2	Common Variable Immunodeficiency 04/2015 - 05/2011
1	Body Weight (Weight, Body) 10/2020
1	Glycogen Storage Disease Type II (Pompe's Disease) 09/2020
1	Nervous System Diseases (Neurological Disorders) 06/2019
1	Hypersensitivity (Allergy) 01/2019
1	Carcinogenesis 06/2018
1	Carcinoma (Carcinomatosis) 01/2018
1	Nijmegen Breakage Syndrome 01/2018
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2018
1	Hemolysis 12/2017
1	DiGeorge Syndrome (Syndrome, DiGeorge) 12/2017
1	Septic Shock (Toxic Shock Syndrome) 12/2017
1	Disease Progression 10/2017
1	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 10/2017
1	Diamond-Blackfan Anemia (Anemia, Diamond Blackfan) 01/2017
1	Anemia 01/2017
1	Food Hypersensitivity (Food Allergy) 01/2016
1	Eosinophilia 01/2016
1	Eczema 01/2016
1	Persistent Infection 09/2015
1	Hemorrhage 04/2015
1	Cytopenia 04/2015
1	Cytokine Release Syndrome 04/2015
1	Lymphoma (Lymphomas) 04/2015
1	Chronic Granulomatous Disease 02/2014
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 08/2011
1	Fanconi Anemia (Fanconi's Anemia) 07/2011
1	Splenomegaly 05/2011
1	Communicable Diseases (Infectious Diseases) 12/2009
1	Primary Immunodeficiency Diseases 12/2009
1	Rare Diseases (Rare Disease) 12/2009
1	Agammaglobulinemia (Hypogammaglobulinemia) 02/2009
1	Failure to Thrive 01/2009
1	Immune System Diseases (Immune Disorders) 11/2007

Drug/Important Bio-Agent (IBA)

16	Adenosine DeaminaseIBA 01/2022 - 09/2005
7	purineIBA 12/2021 - 05/2007
6	EnzymesIBA 12/2021 - 10/2006
4	Immunoglobulins (Immunoglobulin)IBA 06/2020 - 05/2011
4	Signaling Lymphocytic Activation Molecule Associated ProteinIBA 01/2018 - 08/2005
3	pegademase bovine (pegADA)FDA Link 12/2021 - 10/2006
3	Proteins (Proteins, Gene)FDA Link 06/2019 - 10/2017
3	HLA Antigens (Human Leukocyte Antigens)IBA 05/2017 - 09/2006
3	LigandsIBA 05/2011 - 02/2009
2	Pharmaceutical PreparationsIBA 10/2020 - 04/2015
2	Interleukin-2 Receptors (IL 2 Receptor)IBA 06/2018 - 10/2014
2	PerforinIBA 01/2018 - 04/2015
2	CytokinesIBA 01/2016 - 04/2015
2	AntigensIBA 04/2015 - 05/2011
2	Nonsense Codon (Nonsense Mutation)IBA 07/2014 - 05/2007
2	Cytokine Receptors (Cytokine Receptor)IBA 08/2011 - 12/2004
1	Busulfan (Busulfex)FDA Link 10/2020
1	alpha-Glucosidases (Acid Maltase)IBA 09/2020
1	AcidsIBA 09/2020
1	GlycogenIBA 09/2020
1	Recombinases (Recombinase)IBA 06/2020
1	Immunoglobulin M (IgM)IBA 01/2019
1	DNA Ligase ATPIBA 01/2018
1	DNA (Deoxyribonucleic Acid)IBA 01/2018
1	EpitopesIBA 01/2018
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 05/2017
1	Peptide Elongation Factors (Elongation Factor)IBA 01/2017
1	GlobinsIBA 01/2017
1	ribosomal protein S19IBA 01/2017
1	Immunoglobulin E (IgE)IBA 01/2016
1	Rotavirus VaccinesIBA 09/2015
1	Immunomodulating AgentsIBA 04/2015
1	Complementary DNA (cDNA)IBA 10/2014
1	Codon (Codons)IBA 03/2014
1	Anti-Bacterial Agents (Antibiotics)IBA 08/2011
1	Cyclophilins (Cyclophilin)IBA 05/2011
1	CalciumIBA 05/2011
1	ElementsIBA 12/2009
1	gamma-Globulins (gamma-Globulin)IBA 12/2009
1	STAT5 Transcription FactorIBA 02/2009
1	Tyrosine (L-Tyrosine)FDA Link 02/2009
1	Rituximab (Mabthera)FDA Link 09/2007

Therapy/Procedure

13	Transplantation 06/2018 - 09/2006
12	Hematopoietic Stem Cell Transplantation 01/2022 - 05/2007
10	Stem Cell Transplantation 10/2017 - 10/2004
6	Enzyme Replacement Therapy 12/2021 - 05/2007
3	Therapeutics 09/2020 - 11/2007
2	Immunotherapy 12/2021 - 01/2010
2	Antibiotic Prophylaxis 01/2020 - 08/2011
2	Aftercare (After-Treatment) 12/2017 - 04/2015
2	Cell Transplantation 10/2012 - 07/2011
2	Drug Therapy (Chemotherapy) 08/2011 - 11/2008
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 05/2010